Feb 3, 2020

Amino Acid‐Derived Sensors for Specific Zn2+ Detection Using Hyperpolarized 13C Magnetic Resonance Spectroscopy #DNPNMR

Wang, Sinan, David E. Korenchan, Paola M. Perez, Céline Taglang, Thomas R. Hayes, Renuka Sriram, Robert Bok, et al. “Amino Acid‐Derived Sensors for Specific Zn2+ Detection Using Hyperpolarized 13C Magnetic Resonance Spectroscopy.” Chemistry – A European Journal 25, no. 51 (September 12, 2019): 11842–46.


Alterations in Zn2+ homeostasis have been targeted for diagnosis and treatment of human diseases including cancer, diabetes, and neurodegenerative illness. Herein, enriched [113C]cysteine and [1-13C2]iminodiacetic acid were developed as Zn2+specific imaging probes using hyperpolarized 13C magnetic resonance spectroscopy. [1-13C]cysteine was used to accurately quantify Zn2+ in complex biological mixtures. These sensors can be employed to detect Zn2+ via imaging mechanisms including changes in 13C chemical shift, resonance linewidth, or T1.