Aug 5, 2019

[NMR] Postdoctoral position in biomolecular MAS-DNP in Grenoble, France #DNPNMR

Post-doctoral position in MAS-DNP for the study of bacterial cell wall at CEA / Univ. Grenoble Alpes (France)

Application deadline September 1st 

A post-doctoral position is available immediately for a period of 18 months (with possible extension) to work with Sabine Hediger and Gaël De Paëpe on developing MAS-DNP for the study of bacterial cell wall. More information about our group at CEA Grenoble / Univ. Grenoble Alpes and a list of recent publications can be found here: www.dnpgrenoble.net.

Context of the project:
For over 50 years, peptidoglycan has played a pivotal role in the development of antibacterial chemotherapy. In the hunt for new drugs, the biosynthetic pathways of this ubiquitous cell wall polymer have been deciphered and essential peptidoglycan-synthesizing enzymes identified as antibacterial targets with high potential. Focusing on the L,D-transpeptidation, a key cell-wall synthesis and maturation reaction, we will first study purified enzymes in interaction with peptidoglycan fragments and then move on to the study of the complete cell-wall synthesis machinery in bacterial cells during the cell maturation.

Project :
In this context, innovative spectroscopic approaches including MAS-DNP will be conducted to provide new tools for the investigation of protein interaction with the bacterial cell wall. This project aims at developing the available MAS-DNP technique in order to provide best spectral sensitivity and resolution for the investigation of the bacterial cell wall itself in extracted and entire cells, as well as possible interactions with proteins involved in L,D-transpeptidation. These developments will make use of state-of-the-art DNP methods and polarizing agents developed or under development in the lab, which hosts two 400 MHz MAS-DNP spectrometers.

Requirements and application: 
Applicants are expected to have a doctoral degree in liquid-state and/or solid-state biomolecular NMR spectroscopy. Knowledge about MAS-DNP will be considered as a plus. The successful candidate will be recruited for 18 months (with possible extension) and will benefit from an ANR postdoctoral fellowship. Deadline for application is end of August. Interested candidates are welcomed to send an email to both: sabine.hediger@cea.fr and gael.depaepe@cea.fr.

Grenoble is one of the major cities in Europe for research with a large international scientific community. In addition, Grenoble has a large international student population, is a very pleasant city to live in, and is known as the “Capital of the Alps” with easy access to great skiing and hiking. It’s also only 2 hours’ drive to the Mediterranean Sea, Italy, or Switzerland. Grenoble, Lyon, and Geneva airports are nearby and permit straightforward international travel.

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