Aug 23, 2019

[NMR] Postdoc/PhD position in Fluidics for Hyperpolarized Metabolic Magnetic Resonance #DNPNMR

Center for Hyperpolarization in Magnetic Resonance invites applications for a PhD or Post-doc position in Fluidics for Hyperpolarized Metabolic Magnetic Resonance.

Center for Hyperpolarization in Magnetic Resonance (HYPERMAG) is a center of excellence funded by the Danish National Research Foundation. We are part of the Center for Magnetic Resonance (www.cmr.healthtech.dtu.dk) at the department of Health Technology and conduct research in metabolic MRI and NMR. Our research is conducted in collaboration with universities, hospitals and healthcare companies both nationally and internationally. Our main educational responsibility is within the BSc and MSc program in BioMedical Engineering in collaboration with the Faculty of Health Sciences, University of Copenhagen.

Our mission is to address basic scientific questions of hyperpolarization by Dynamic Nuclear Polarization (DNP) to enable new applications of Magnetic Resonance in the study of biochemical reactions in real-time in vivo and in vitro. The group has high-resolution NMR systems of various types (e.g. Agilent, RS2D and Magritek), several polarizers (home-built and Hypersense), a cell lab, chemistry lab and electronics labs. We are 20-25 researchers and support staff.

Responsibilities and tasks
You will be responsible for 

  • The development of a robust sample transfer system between the dDNP polarizer and NMR equipment. With the purpose to reproducibly conduct metabolite identification experiments (fast transfer of bulk samples) and to conduct tracer studies in cell suspension (transfer of substrates and mixing with cells/infusion of hyperpolarized substrate). In particularly to ensure fast, automated and efficient transfer and mixing of the cells with the hyperpolarized substrate.
  • Making the transfer and mixing system compatible with a bioreactor for longitudinal studies of cell cultures.
  • As a PhD student you will further be responsible to apply the integrated transfer, mixing and bioreactor system on specific biological systems.
  • As a Post doc you will be a key collaborator for the biological sub-group of HYPERMAG for the application of the integrated transfer, mixing and bioreactor system to longitudinal studies on various cell lines in other projects.
Qualifications
Candidates should hold a Master (PhD position) or PhD degree (postdoc position) within the field of analytical chemistry or equivalent.

  • Hands on experience with fluidics and mechanics such as HPLC systems
  • Core interest in development of technical solutions for biological research
  • Experience with NMR
  • Experience with cell studies
  • You are driven by pushing boundaries
  • You enjoy working with complex topics
  • You are motivated by both individual and team accomplishment
Approval and Enrolment (only relevant for PhD candidates)
The scholarship for the PhD degree is subject to academic approval, and the candidate will be enrolled in one of the general degree programmes at DTU. For information about our enrolment requirements and the general planning of the PhD study programme, please see the DTU PhD Guide

We offer
DTU is a leading technical university globally recognized for the excellence of its research, education, innovation and scientific advice. We offer a rewarding and challenging job in an international environment. We strive for academic excellence in an environment characterized by collegial respect and academic freedom tempered by responsibility.

Salary and terms of employment
The appointment will be based on the collective agreement with the Danish Confederation of Professional Associations. The allowance will be agreed upon with the relevant union. The PhD position is for 3 years. The postdoc position is for 2 years.

The work place is DTU Lyngby campus.

You can read more about career paths at DTU here

Further information

Further information may be obtained from Prof. Jan Ardenkjær-Larsen, tel.: +45 4525 3918.

You can read more about DTU Health Tech at www.healthtech.dtu.dk/english

Application procedure
Please submit your online application (Postdoc/PhD position in Fluidics for Hyperpolarized Metabolic Magnetic Resonance) no later than 15 September 2019 (local time). Applications must be submitted as one PDF file containing all materials to be given consideration. To apply, please open the link "Apply online", fill out the online application form, and attach all your materials in English in one PDF file. The file must include: 

  • A letter motivating the application (cover letter)
  • Curriculum vitae
  • Grade transcripts and BSc/MSc diploma
  • PhD diploma (if applying for a post-doc position)
  • Excel sheet with translation of grades to the Danish grading system (see guidelines and Excel spreadsheet here - if applying for a PhD position)
Candidates may apply for a PhD position prior to obtaining their master's degree but cannot begin before having received it.

Applications and enclosures received after the deadline will not be considered.

All interested candidates irrespective of age, gender, disability, race, religion or ethnic background are encouraged to apply.

Jan Henrik Ardenkjær-Larsen
Professor and Section Head
Technical University of Denmark 
Department of Health Technology
Ørsted Plads, bldg 349, office 126
DK - 2800 Kgs. Lyngby
Phone +45 45253918
Mobile +45 40272775



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