Jun 17, 2019

Combination of OPSY and PhD-PHIP results in enhanced sensitivity in PHIP

Bussandri, S., L. Buljubasich, and R.H. Acosta. “Combination of OPSY and PhD-PHIP Results in Enhanced Sensitivity in PHIP.” Journal of Magnetic Resonance 299 (February 2019): 28–32. 


Despite the large degree of polarization in PHIP experiments compared to the Boltzmann factor, the presence of a large amount of non-reacted molecules with thermal polarization is an important obstacle when dealing with very diluted samples. The feasibility of enhancing both sensitivity and resolution in a single experiment by combining two well established pulse sequences, OPSY and PHD-PHIP is presented. OPSY is used as a block for filtering the signals originated from thermally polarized protons. PhD-PHIP, on the other hand, is used as an acquisition block, increasing the resolution and further improving the sensitivity by preventing signal canceling in the presence of magnetic field inhomogeneities. Experiments in a complex sample with very low hyperpolarization levels are presented showing the excellent performance of the method.