Mar 19, 2019

DNP-enhanced NMR studies of cellular membrane disruption induced by Abeta40 peptides. #DNPNMR

DNP-enhanced NMR studies of cellular membrane disruption induced by Abeta40 peptides.

Supervisor: Dr Alexey Potapov

We are looking for a motivated PhD candidate interested in biophysical applications of magnetic resonance spectroscopy. This position is suitable for students with background in Physics, Chemistry or other related fields.

Aggregates of amyloid-beta peptides have been proposed to play role in causing Alzheimer's disease, however, their mechanism of action is not clearly understood. In this project, carried out in collaboration with SUNY Binghamton (USA), we focus on the process of cell membrane disruption by amyloid-beta and study its details using advanced nuclear magnetic resonance (NMR) techniques. One of such techniques is the dynamic nuclear polarization (DNP) allowing the NMR signals to be increased by a large factor. University of Nottingham is hosting a modern DNP-enhanced solid-state NMR Facility (unique in the UK) funded by a grant of £2.5 M from EPSRC.

The PhD studentship is available immediately, and is fully funded for 3.5 years via a stipend covering PhD tuition fees (at the UK/EU rate) and a tax-free living allowance.

The Sir Peter Mansfield Imaging Centre, which is part of the School of Physics and Astronomy of the University of Nottingham, is well equipped and conducts a very active research program in many aspects of modern magnetic resonance (http://www.nottingham.ac.uk/magres/index.aspx). For more details please contact Dr Alexey Potapov (alexey.potapov@nottingham.ac.uk)

Dr Alexey Potapov
Assistant Professor in Magnetic Resonance
Sir Peter Mansfield Imaging Center
School of Physics and Astronomy
University of Nottingham
Nottingham NG7 2RD United Kingdom
p: (44) 115 951 4739

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