Feb 18, 2020

[NMR] Research Assistant: Hyperpolarized Gas and Pulmonary MRI #DNPNMR

The Center for Pulmonary Imaging Research (CPIR) at Cincinnati Children’s Hospital Medical Center (CCHMC) is soliciting applications for a staff position at the level of Research Assistant II. Highly qualified applicants will be considered at the RA III level. The CPIR is a multidisciplinary center affiliated with the Radiology, Neonatology, and Pulmonary Medicine. CCHMC is currently ranked #4 in the U.S. in Pulmonary Medicine and ranked #3 overall in Pediatric Medicine. The CPIR focuses on hyperpolarized gas and proton NMR and MRI of the respiratory system, with the goal of understanding pulmonary and airway structure and function in children and adults with a wide range of chronic respiratory disorders, including cystic fibrosis, asthma, rare-lung diseases and lung-transplantation rejection. Team members have backgrounds that range from atomic physics and physical chemistry, to engineering, to pulmonary medicine and biology and collaborate to perform cutting-edge research in animal models and humans subjects of all ages. (Website:

Position Requirements and Responsibilities: The candidate must have at least B.S. or B.A. in a physical science (i.e., chemistry or physics), engineering, or related discipline. Recent graduates are encouraged to apply. Experience with magnetic resonance, electronics, high-pressures, glassware, or coding experience (MATLAB, C++, python) is desired. The accepted applicant will possess excellent communication skills, strong attention to detail, and the desire to promote a safe working environment. The abilities to synthesize information, learn new skills, and teach others in a dynamic, multidisciplinary environment are essential.

Job responsibilities will include producing hyperpolarized gas using commercial and homebuilt equipment, maintaining and developing specialized equipment, following and revising standard operating procedures (SOPs), and documenting compliance with FDA and institutional regulations. The applicant will also collect and analyze imaging data after appropriate training.

To Apply: Please submit a cover letter, a resume detailing research experience and technical expertise, and the names and contact information of three references by email to Carolyn Lipchik. (Carolyn.Lipchik@cchmc.org).

Cincinnati Children’s is an Equal Opportunity Employer. Qualified applicants receive consideration for employment without regard to race, color, religion, sex, national origin, age, genetic information, physical or mental disability, military or veteran status, sexual orientation, gender identity/expression, or other protected status in accordance with applicable federal, state, and local laws and regulations.

Cincinnati Children’s will not discriminate against applicants and employees for inquiring about, discussing or disclosing their pay or, in certain circumstances, the pay of their co-workers.

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[NMR] International School for Young Scientists on Magnetic Resonance and Magnetic Phenomena

Dear colleagues,

We cordially invite you to participate in the VI International School for Young Scientists: Magnetic Resonance and Magnetic Phenomena in Chemical and Biological Physics, which will be held in Roshchino, St. Petersburg (Leningrad) region, Russia on September 5-10, 2020. 

The scope of the school is relatively broad, and its key purpose is to present interconnected topics in NMR and EPR spectroscopy in a form that underlines their fundamental similarity. Currently in several areas of research the two spectroscopies interconnect, thus building up new promising approaches, of which, probably, hyperpolarization and paramagnetic NMR are the most known and broadly used examples. We intend approaching the basic mechanisms responsible for the polarization transfer from electrons to nuclei both from NMR and EPR side. Similarities and differences in electron and nuclear relaxation and dipolar interactions will be in the focus of this school, as well.

The school includes lectures and tutorials on pulsed EPR, pulsed NMR, spin hyperpolarization and spin chemistry, including chemically induced spin polarization. A feature of the School is to approach these apparently different topics within a common theoretical framework, with the intention to obtain deeper understanding of spin dynamics of coupled electron-nuclear systems. Another aim of the School is to provide the participants with systematic knowledge of the mechanisms of the action of pulse sequences commonly used in modern EPR and NMR. We will also discuss in depth the interplay of electron and nuclear spins in modern EPR and NMR experimental methods. Furthermore, effects of electron and nuclear spins on chemical reactivity, playing a major role in spin chemistry, will be considered.

The program will include lectures and practical tutorials. The composition of the program will allow the participants to learn how to describe spin dynamics in pulse EPR and NMR experiments and, ultimately, to design novel magnetic resonance experiments. The meeting will be limited to 50 participants (not counting lecturers). The working language is English.

Registration deadline is 1 June 2020. Registration fee is 200 Euro for foreign participants and 12000 Roubles for Russian participants, which covers participation in all scientific sessions, coffee-breaks, welcome party, conference materials, cultural program, breakfast and lunch. For AMPERE members the fee is reduced.

The teachers are:

Christian Griesinger (Göttingen, Germany) 
Leonid Kulik (Novosibirsk, Russia)
Olivier Lafon (Lille, France)
P. K. Madhu (Hyderabad, India)
Kiminori Maeda (Saitama, Japan) 
Valentin Novikov (Moscow, Russia)
Maxim Yulikov (Zurich, Switzerland)

More information is available at the web-site of the School: http://roshchino2020.tomo.nsc.ru/
Please encourage your young colleagues to participate in this event.
Sincerely yours,

Prof. Konstantin Ivanov, co-chairmanProf. Leonid Kulik, co-chairman
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Feb 17, 2020

1st International EPR-on-a-chip Workshop

EPR-on-a-chip is an emerging technology that aims at providing the analytical power of electron paramagnetic resonance (EPR) spectroscopy in the tiny form factor of a millimeter-sized microchip.

Within the BMBF sponsored research project EPRoC, the possibilities of this new and fascinating technology are evaluated in the context of operando EPR measurements on energy materials.

The goal of the 1st International EPR-on-a-chip Workshop is to serve as a forum for discussing the possibilities of the EPR-on-a-chip technology in other disciplines, including catalysis, biology and medicine.

The application of novel Ir-NHC polarization transfer complexes by SABRE #DNPNMR #SABRE

Hadjiali, Sara, Marvin Bergmann, Alexey Kiryutin, Stephan Knecht, Grit Sauer, Markus Plaumann, Hans-Heinrich Limbach, Herbert Plenio, and Gerd Buntkowsky. “The Application of Novel Ir-NHC Polarization Transfer Complexes by SABRE.” The Journal of Chemical Physics 151, no. 24 (December 28, 2019): 244201.

In recent years, the hyperpolarization method Signal Amplification By Reversible Exchange (SABRE) has developed into a powerful technique to enhance Nuclear Magnetic Resonance (NMR) signals of organic substrates in solution (mostly via binding to the nitrogen lone pair of N-heterocyclic compounds) by several orders of magnitude. In order to establish the application and development of SABRE as a hyperpolarization method for medical imaging, the separation of the Ir-N-Heterocyclic Carbene (Ir-NHC) complex, which facilitates the hyperpolarization of the substrates in solution, is indispensable. Here, we report for the first time the use of novel Ir-NHC complexes with a polymer unit substitution in the backbone of N-Heterocyclic Carbenes (NHC) for SABRE hyperpolarization, which permits the removal of the complexes from solution after the hyperpolarization of a target substrate has been generated.

Feb 14, 2020

DNP Mechanisms #DNPNMR

Kundu, Krishnendu, Frédéric Mentink‐Vigier, Akiva Feintuch, and Shimon Vega. “DNP Mechanisms.” In EMagRes, 295–338. American Cancer Society, 2019.

This article presents a comprehensive description of the spin dynamics underlying the main DNP mechanisms leading to nuclear signal enhancements in glassy amorphous solids containing free radicals. The emphasis of the article to derive quantum mechanically based formalisms that enable us to analyze experimental DNP data. After a short review of the history of DNP, rate equations of the eigenstate populations of static coupled electron–nuclear spin systems are introduced, based on their spin-Hamiltonians and including spin-lattice and cross-relaxation mechanisms. They are used to simulate the dynamics of small spin systems under microwave (MW) irradiation and the basic Solid Effect (SE), Cross Effect (CE), and Overhauser DNP (O-DNP) enhancement mechanisms are presented. These calculations are then extended to systems containing up to 10 spins and are used to calculate EPR, ELDOR, and DNP spectra. Plots showing the population of the eigenstates vs energy are used to demonstrate the conditions for the thermal mixing mechanism and the corresponding EPR and ELDOR spectra are discussed. Following these calculations, the electron spectral diffusion (eSD) and the indirect Cross Effect (iCE) numerical models are introduced and used to analyze EPR and DNP spectra of real samples. In the last section, the basic theory of magic angle spinning (MAS) DNP on small spin systems is summarized and the influence of the rotor events on the quasiperiodic steady-state DNP enhancements discussed. The origins of depolarization effects occurring when no MW is applied are described. Finally, the nuclear spin diffusion process inside the diffusion barrier is studied using multielectron and multinuclear calculations.

Feb 12, 2020

[NMR] RF instrumentation position at NHMFL

RF instrumentation position is open at National High Magnetic Field Laboratory in Tallahassee, Florida, funded by a P41 grant from National Institutes of Health:

Responsibilities include carrying out engineering, R&D and operational tasks associated with high field NMR magnet systems, NMR spectrometers, radio-frequency NMR probes and associated technologies. Responsibilities include supporting the development of new capabilities for chemical and biological NMR in resistive, hybrid and superconducting magnets in the NHMFL user facility. The employee will provide instrumentation support to users on high-field NMR systems. Will participate in design and construction of the high-field solid state NMR probes. The employee will work with magnet designers and other technical staff members to refine the homogeneity and regulation of magnetic fields in high-field magnets. The successful applicant will work on a variety of R&D and engineering activities associated with the development of new NMR research facilities.

Seeking candidates who are motivated and eager to work flexibly and creatively in a cross-disciplinary team environment. Good communications skills and the ability to interact constructively with physicists, chemists, engineers, designers, technicians and procurement personnel Experience working with NMR spectrometers, NMR probes and RF amplifiers. Familiar with RF measurement tools including, but not limited to use of a Vector Network Analyzer. Experience with RF circuit design modeling software. Experience with EM field simulation software. Experience with CAD software for mechanical design. Familiarity with NMR principles and experimental methods.

Qualifications: Ph.D. in Electrical Engineering, Physics, Chemistry, or in a closely related field; or an M.S. with at least two years post-graduate experience.

For inquiries, please contact Peter Gor'kov (pgorkov@magnet.fsu.edu). For a complete position description please go to https://hr.fsu.edu/index.cfm?page=ers/ers_home then click "Job Opportunities" and search for "47127" (a job ID). To apply for this position please click "Apply for Job" button on the job description page.

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[NMR] 53rd Royal Society of Chemistry ESR Group Meeting - deadline approaching #DNPNMR #EPR

Dear Colleagues,

the registration deadline for the 53rd Annual Meeting of the ESR Group of the Royal Society of Chemistry is on 21 February. If you plan to attend, please register here:

The Meeting is the longest running EPR spectroscopy conference in the world, as well as the occasion on which the EPR Bruker Prizes are awarded for the best PhD thesis (junior level) and the best scientific accomplishment (senior level). The meeting also hosts IES Poster Prizes, and the JEOL Medal, awarded for the best student presentation. In the annual cycle of the EPR spectroscopy community, this conference is the central event.

This year’s Meeting will take place in Manchester between 29th Mar and 2nd Apr 2020. The registration is open and may be accessed via the link above.

Best wishes,

Dr Ilya Kuprov FRSC
Associate Professor of Chemical Physics
Secretary to the RSC ESR Spectroscopy Group
Associate Editor, Science Advances
Office 3041, Building 30,
School of Chemistry, FNES,
University of Southampton,
Southampton, SO17 1BJ, UK.
Tel: +44 2380 594 140

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