Monday, November 26, 2018

Rossini, Aaron J. “Materials Characterization by Dynamic Nuclear Polarization-Enhanced Solid-State NMR Spectroscopy.” The Journal of Physical Chemistry Letters 9, no. 17 (September 6, 2018): 5150–59.

High-resolution solid-state NMR spectroscopy is a powerful tool for the study of organic and inorganic materials because it can directly probe the symmetry and structure at nuclear sites, the connectivity/bonding of atoms and precisely measure inter-atomic distances. However, NMR spectroscopy is hampered by intrinsically poor sensitivity, consequently, the application of NMR spectroscopy to many solid materials is often infeasible. High-field dynamic nuclear polarization (DNP) has emerged as a technique to routinely enhance the sensitivity of solid-state NMR experiments by one to three orders of magnitude. This perspective gives a general overview of how DNP-enhanced solid-state NMR spectroscopy can be applied to a variety of inorganic and organic materials. DNP-enhanced solid-state NMR experiments provide unique insights into the molecular structure, which makes it possible to form structure-activity relationships that ultimately assist in the rational design and improvement of materials.