Friday, August 31, 2018

Electron-driven spin diffusion supports crossing the diffusion barrier in MAS DNP #DNPNMR

Wittmann, Johannes J., Michael Eckardt, Wolfgang Harneit, and Björn Corzilius. “Electron-Driven Spin Diffusion Supports Crossing the Diffusion Barrier in MAS DNP.” Physical Chemistry Chemical Physics 20, no. 16 (2018): 11418–29.

Dynamic nuclear polarization (DNP) can be applied to enhance the sensitivity of solid-state NMR experiments by several orders of magnitude due to microwave-driven transfer of spin polarization from unpaired electrons to nuclei. While the underlying quantum mechanical aspects are sufficiently well understood on a microscopic level, the exact description of the large-scale spin dynamics, usually involving hundreds to thousands of nuclear spins per electron, is still lacking consensus. Generally, it is assumed that nuclear hyperpolarization can only be observed on nuclei which do not experience strong influence of the unpaired electrons and thus being significantly removed from the paramagnetic polarizing agents. At the same time, sufficiently strong hyperfine interaction is required for DNP transfer. Therefore, efficient nuclear spin diffusion from the strongly-interacting nuclei to the NMR-observable bulk is considered to be essential for efficient nuclear hyperpolarization. Based on experimental results obtained on the endohedral fullerene N@C60 as a polarizing agent sparsely diluted in C60, we discuss the effect of the spin-diffusion barrier. We introduce electron-driven spin diffusion (EDSD) as a novel mechanism for nuclear polarization transfer in the proximity of an electron spin which is particularly relevant under magic-angle spinning (MAS) DNP conditions.

Wednesday, August 29, 2018

Amplification of Dynamic Nuclear Polarization at 200 GHz by Arbitrary Pulse Shaping of the Electron Spin Saturation Profile #DNPNMR

Kaminker, Ilia, and Songi Han. “Amplification of Dynamic Nuclear Polarization at 200 GHz by Arbitrary Pulse Shaping of the Electron Spin Saturation Profile.” The Journal of Physical Chemistry Letters 9, no. 11 (June 7, 2018): 3110–15.

Dynamic nuclear polarization (DNP) takes center stage in nuclear magnetic resonance (NMR) as a tool to amplify its signal by orders of magnitude through the transfer of polarization from electron to nuclear spins. In contrast to modern NMR and electron paramagnetic resonance (EPR) that extensively rely on pulses for spin manipulation in the time domain, the current mainstream DNP technology exclusively relies on monochromatic continuous wave (CW) irradiation. This study introduces arbitrary phase shaped pulses that constitute a train of coherent chirp pulses in the time domain at 200 GHz (7 T) to dramatically enhance the saturation bandwidth and DNP performance compared to CW DNP, yielding up to 500-fold in NMR signal enhancements. The observed improvement is attributed to the recruitment of additional electron spins contributing to DNP via the cross-effect mechanism, as experimentally confirmed by two-frequency pump–probe electron–electron double resonance (ELDOR).

Monday, August 27, 2018

Direct observation of Ru-alkylidene forming into ethylene in ring-closing metathesis from hyperpolarized 1H NMR #DNPNMR

Kim, Yaewon, Chia-Hsiu Chen, and Christian Hilty. “Direct Observation of Ru-Alkylidene Forming into Ethylene in Ring-Closing Metathesis from Hyperpolarized 1H NMR.” Chemical Communications 54, no. 34 (2018): 4333–36.

Ring-closing metathesis was monitored using real-time NMR of 1H hyperpolarized olefins at room temperature. By applying a selective saturation to an observable intermediate, its protons were found to transfer to ethylene. The intermediate was thus identified as a Ru-alkylidene species, which appears in the ethylene formation pathway.

Friday, August 24, 2018

Dynamic Nuclear Polarization Opens New Perspectives for NMR Spectroscopy in Analytical Chemistry #DNPNMR

Plainchont, B., P. Berruyer, J. N. Dumez, S. Jannin, and P. Giraudeau. “Dynamic Nuclear Polarization Opens New Perspectives for NMR Spectroscopy in Analytical Chemistry.” Analytical Chemistry 90 (March 20, 2018): 3639–50.

Dynamic nuclear polarization (DNP) can boost sensitivity in nuclear magnetic resonance (NMR) experiments by several orders of magnitude. This Feature illustrates how the coupling of DNP with both liquid- and solid-state NMR spectroscopy has the potential to considerably extend the range of applications of NMR in analytical chemistry.

Wednesday, August 22, 2018

Using a local low rank plus sparse reconstruction to accelerate dynamic hyperpolarized 13C imaging using the bSSFP sequence

Milshteyn, Eugene, Cornelius von Morze, Galen D. Reed, Hong Shang, Peter J. Shin, Peder E. Z. Larson, and Daniel B. Vigneron. “Using a Local Low Rank plus Sparse Reconstruction to Accelerate Dynamic Hyperpolarized 13C Imaging Using the BSSFP Sequence.” Journal of Magnetic Resonance 290 (May 1, 2018): 46–59.

Acceleration of dynamic 2D (T2 Mapping) and 3D hyperpolarized 13C MRI acquisitions using the balanced steady-state free precession sequence was achieved with a specialized reconstruction method, based on the combination of low rank plus sparse and local low rank reconstructions. Methods were validated using both retrospectively and prospectively undersampled in vivo data from normal rats and tumor-bearing mice. Four-fold acceleration of 1–2 mm isotropic 3D dynamic acquisitions with 2–5 s temporal resolution and two-fold acceleration of 0.25–1 mm2 2D dynamic acquisitions was achieved. This enabled visualization of the biodistribution of [2-13C]pyruvate, [1-13C]lactate, [13C, 15N2]urea, and HP001 within heart, kidneys, vasculature, and tumor, as well as calculation of high resolution T2 maps.

Tuesday, August 21, 2018

[NMR] Postdoctoral position in EPR spectroscopy

Dear Colleagues:

The Department of Chemistry at the University of Virginia invites applications for a Postdoctoral Research Associate, who is excited about the opportunity to work in a dynamic and collaborative research environment. The successful candidate will participate in collaborative work in the Membrane Biology Center at the University of Virginia, and will be engaged in research directed at the molecular structure and dynamics of proteins that mediate neuronal exocytosis using modern pulse EPR spectroscopy.

This is a one year appointment; however appointment may be renewed for an additional two, one-year increments, contingent upon available funding and satisfactory performance.

Requirements for the position include the completion of a Ph.D. degree in Chemistry, Biochemistry or a related discipline by the appointment start date, and effective oral and written communication skills. The candidate must have a working knowledge of biochemical and molecular biological laboratory procedures, and should have expertise in the expression and purification of SNAREs or related proteins. The candidate is also expected to have expertise in magnetic resonance spectroscopy, with a familiarity of EPR spectroscopy and modern pulse EPR instrumentation. The successful candidate is also expected to help mentor undergraduates and graduate students in the laboratory. 

To apply, please submit a candidate profile on-line through Jobs@UVA ( and electronically attach the following: cover letter, curriculum vitae, and the contact information for three (3) references; search on posting number 0623594. 

Review of applications will begin July 16, 2018; however, the position will remain open until filled. 

Questions regarding this position should be directed to: 
Prof. David Cafiso 
(434) 924-3067 

Questions regarding the Candidate Profile process or Jobs@UVA should be directed to: or 434-9982-0123 

The University will perform background checks on all new hires prior to making a final offer of employment. 

The University of Virginia is an affirmative action/equal opportunity employer committed to diversity, equity, and inclusiveness. Women Minorities, Veterans and Persons with Disabilities are encouraged to apply. 

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[NMR] Postdoctoral position in NMR of materials for energy storage at UCSB (Santa Barbara, USA)

Postdoctoral position in NMR of materials for energy storage at UCSB (Santa Barbara, USA)

The postdoctoral research position is based at the Materials Department, University of California Santa Barbara (UCSB), in the group of Prof. Raphaële Clément. The position is available from October, 1st, 2018, with an initial one-year contract renewable upon mutual agreement for two additional years.

Project Description

The research program focuses on the study of paramagnetic rechargeable battery materials using a variety of solid-state NMR (and EPR) techniques. The work will be in close collaboration with the Lawrence Berkeley National Laboratory, as well as other U.S. Universities and research groups at UCSB. In addition to developing a deep understanding of structure-property relationships for battery electrode materials, the postdoctoral researcher will be given the opportunity to acquire new experimental skills such as the solid-state synthesis of electrodes, and the preparation and testing of electrochemical cells. A strong emphasis will be placed on the combined use of experimental and theoretical tools to investigate changes in the local structure and electrochemical processes taking place during charge and discharge. Specifically, the interpretation of experimental paramagnetic NMR (and EPR) data will be assisted by first principles calculations of paramagnetic NMR/EPR parameters (an area of expertise of our group), and by insights gained from Monte Carlo and density functional theory simulations of electrode materials at different stages of the charge/discharge cycle (through ongoing collaborations). 
Relevant publications

[1] Lee, J.; Kitchaev, D. A.; Kwon, D.-H.; Lee, C.-W.; Papp, J. K.; Liu, Y.-S.; Lun, Z.; Clément, R. J.; Shi, T.; McCloskey, B. D.; Guo, J.; Balasubramanian, M.; Ceder, G. Nature 2018, 556 (7700), 185.

[2] Lee, J.; Papp, J. K.; Clément, R. J.; Sallis, S.; Kwon, D.-H.; Shi, T.; Yang, W.; McCloskey, B. D.; Ceder, G. Nat. Commun. 2017, 8 (1), 981.

[3] Kitchaev, D. A.; Lun, Z.; Richards, W. D.; Ji, H.; Clément, R. J.; Balasubramanian, M.; Kwon, D.-H.; Dai, K.; Papp, J. K.; Lei, T.; McCloskey, B. D.; Yang, W.; Lee, J.; Ceder, G. Energy Environ. Sci. 2018, 104, 4271.

[4] Clément, R. J.; Pell, A. J.; Middlemiss, D. S.; Strobridge, F. C.; Miller, J. K.; Whittingham, M. S.; Emsley, L.; Grey, C. P.; Pintacuda, G. J. Am. Chem. Soc. 2012, 134 (41), 17178.

[5] Middlemiss, D. S.; Ilott, A. J.; Clément, R. J.; Strobridge, F. C.; Grey, C. P. Chem. Mater. 2013, 25 (9), 1723.
Requirements and Preferred Experience

The requirements for the position are a Ph.D. in Chemistry, Materials Science, Physics or Engineering, and experience with standard solid-state NMR techniques (e.g. CP/MAS, REDOR, etc.). Experience with paramagnetic NMR and/or EPR is a plus. In addition to performing research, the postdoc will be expected to provide assistance with the training of graduate and undergraduate students.

The Magnetic Resonance Facilities at UCSB

The spectroscopy facility of the Materials Research Laboratory at UCSB (see comprises an X-band EPR spectrometer as well as several solid-state NMR spectrometers, including a 300 MHz system equipped with a MRI/diffusion probe, a 400 MHz DNP-NMR spectrometer, and 500 MHz and 800 MHz systems. All spectrometers are equipped with a range of MAS probes, with a fast spinning 1.3 mm probe (60 kHz MAS) available on the 500 MHz system. In addition, the Terahertz facility at UCSB ( is uniquely equipped with a high field high power EPR system.

Additional Information

Interested candidates should send a cover letter, a résumé (including a list of publications), and the names and email addresses of at least two references to
Raphaële Clément

Assistant Professor, Materials Department
Materials Research Laboratory, Room 3009
University of California, Santa Barbara, CA 93106-5121

Phone: 805-893-4294

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[NMR] postdoctoral position at UC Santa Cruz

Dear Colleagues,
I am please to announce the opening of a postdoctoral researcher position in the Department of Chemistry and Biochemistry at UC Santa Cruz. The selected individual should have demonstrated expertise in Double Electron-Electron Resonance (DEER) EPR. Research will focus on structural biology issues related to neurodegenerative diseases, as well as the facilitation of diverse collaborative studies among California Bay Area labs including UCSF, UC Merced, UC Davis and Stanford. Please see our website: 

and the job posting: 
With best regards,

Glenn L. Millhauser
Department of Chemistry & Biochemistry
UC Santa Cruz
Santa Cruz, CA 95064
831 459 2176 voice
831 566 3337 cell
831 459 2935 fax

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Monday, August 20, 2018

Effect of water/glycerol polymorphism on dynamic nuclear polarization #DNPNMR

Leavesley, Alisa, Christopher B. Wilson, Mark Sherwin, and Songi Han. “Effect of Water/Glycerol Polymorphism on Dynamic Nuclear Polarization.” Physical Chemistry Chemical Physics 20, no. 15 (April 18, 2018): 9897–9903.

A paramount feature of robust experimental methods is acquiring consistent data. However, in dynamic nuclear polarization (DNP), it has been observed that the DNP-induced NMR signal enhancement of nominally the same sample can vary between different experimental sessions. We investigated the impact of various freezing conditions on the DNP results for a standard sample, a 50/40/10 by volume d8-glycerol/D2O/H2O solution of 40 mM 4-amino TEMPO, and found that annealing the samples 10 K above the glass transition temperature (Tg) causes significant changes to the DNP profiles and enhancements compared to that in rapidly frozen samples. When varying the glycerol composition to yield a solution of 60/30/10 d8-glycerol/D2O/H2O, the DNP performance became markedly more consistent, even for samples prepared under vastly different sample freezing methods, in stark contrast with that of the 50/40/10 solution. The EPR lineshapes, Tm, and glass transition temperature, Tg, were measured under the same sample and experimental conditions as used for the DNP experiments to support the conclusion that different freezing methods change the distribution of 4-amino TEMPO radials in the 50/40/10 solution due to the formation of different polymorphs of the glass, which is mitigated in the 60/30/10 solution and is consistent with the water/glycerol vitrification literature.

Friday, August 17, 2018

Dynamic Nuclear Polarization Surface Enhanced NMR spectroscopy (DNP SENS): Principles, protocols, and practice #DNPNMR

Liao, Wei-Chih, Behnaz Ghaffari, Christopher P. Gordon, Jun Xu, and Christophe Copéret. “Dynamic Nuclear Polarization Surface Enhanced NMR Spectroscopy (DNP SENS): Principles, Protocols, and Practice.” Current Opinion in Colloid & Interface Science 33 (January 1, 2018): 63–71.

Dynamic Nuclear Polarization Surface Enhanced NMR spectroscopy has been demonstrated to significantly improve NMR sensitivity on materials by 1 to 2 orders of magnitude at high magnetic fields. The preferential surface enhancement also allows for selectively probing the solid surface. In this review, we will briefly describe the main mechanism used nowadays, i.e. cross effect, for DNP enhanced solid-state NMR. We will show the typical protocols of sample formulation leading to effective DNP surface enhancements and the key experimental factors in performing DNP SENS experiments. Other important developments in DNP, i.e. shielded polarizing agents for reactive surfaces, hyperpolarizing solid matrices, and high-temperature and high-field DNP, will be discussed as well. Finally, we close the review with a short summary and our perspectives on the directions of future developments in this field.

Wednesday, August 15, 2018

Considering low-rank, sparse and gas-inflow effects constraints for accelerated pulmonary dynamic hyperpolarized 129Xe MRI

Xiao, Sa, He Deng, Caohui Duan, Junshuai Xie, Huiting Zhang, Xianping Sun, Chaohui Ye, and Xin Zhou. “Considering Low-Rank, Sparse and Gas-Inflow Effects Constraints for Accelerated Pulmonary Dynamic Hyperpolarized 129Xe MRI.” Journal of Magnetic Resonance 290 (May 1, 2018): 29–37.

Dynamic hyperpolarized (HP) 129Xe MRI is able to visualize the process of lung ventilation, which potentially provides unique information about lung physiology and pathophysiology. However, the longitudinal magnetization of HP 129Xe is nonrenewable, making it difficult to achieve high image quality while maintaining high temporal-spatial resolution in the pulmonary dynamic MRI. In this paper, we propose a new accelerated dynamic HP 129Xe MRI scheme incorporating the low-rank, sparse and gas-inflow effects (L + S + G) constraints. According to the gas-inflow effects of HP gas during the lung inspiratory process, a variable-flip-angle (VFA) strategy is designed to compensate for the rapid attenuation of the magnetization. After undersampling k-space data, an effective reconstruction algorithm considering the low-rank, sparse and gas-inflow effects constraints is developed to reconstruct dynamic MR images. In this way, the temporal and spatial resolution of dynamic MR images is improved and the artifacts are lessened. Simulation and in vivo experiments implemented on the phantom and healthy volunteers demonstrate that the proposed method is not only feasible and effective to compensate for the decay of the magnetization, but also has a significant improvement compared with the conventional reconstruction algorithms (P-values are less than 0.05). This confirms the superior performance of the proposed designs and their ability to maintain high quality and temporal-spatial resolution.

Monday, August 13, 2018

Magic angle spinning NMR with metallized rotors as cylindrical microwave resonators #DNPNMR

Scott, Faith J., Erika L. Sesti, Eric J. Choi, Alexander J. Laut, Jagadishwar R. Sirigiri, and Alexander B. Barnes. “Magic Angle Spinning NMR with Metallized Rotors as Cylindrical Microwave Resonators.” Magnetic Resonance in Chemistry, May 16, 2018.

We introduce a novel design for millimeter wave electromagnetic structures within magic angle spinning (MAS) rotors. In this demonstration, a copper coating is vacuum deposited onto the outside surface of a sapphire rotor at a thickness of 50 nanometers. This thickness is sufficient to reflect 197 GHz microwaves, yet not too thick as to interfere with radiofrequency fields at 300 MHz or prevent sample spinning due to eddy currents. Electromagnetic simulations of an idealized rotor geometry show a microwave quality factor of 148. MAS experiments with sample rotation frequencies of ωr/2π = 5.4 kHz demonstrate that the drag force due to eddy currents within the copper does not prevent sample spinning. Spectra of sodium acetate show resolved 13C J-couplings of 60 Hz and no appreciable broadening between coated and uncoated sapphire rotors, demonstrating that the copper coating does not prevent shimming and high-resolution NMR spectroscopy. Additionally, 13C Rabi nutation curves of ω1/2π = 103 kHz for both coated and uncoated rotors indicate no detrimental impact of the copper coating on radiofrequency coupling of the nuclear spins to the sample coil. We present this metal coated rotor as a first step towards an MAS resonator. MAS resonators are expected to have a significant impact on developments in electron decoupling, pulsed DNP, room temperature DNP, DNP with low power microwave sources, and EPR detection.

[NMR] DNP postdoctoral position at UCSD

The Debelouchina lab at the University of California, San Diego is looking for a postdoctoral researcher with experience and/or interest in DNP to join our growing team. The position will involve the development of new DNP biradical polarization agents and their application to biological systems and materials. Candidates must hold a Ph.D. in chemistry, physics or a related discipline and have experience in solid-state NMR, hyperpolarization techniques or EPR. The project will take advantage of a new 600 MHz DNP spectrometer, scheduled for installation in the fall of 2018.

In addition, the University of California, San Diego has outstanding resources for high-field NMR spectroscopy, including 900 MHz, 750 MHz, 700 MHz and 500 MHz solid-state NMR spectrometers equipped with MAS and static probes, as well as solution spectrometers operating at 800 MHz, 600 MHz and 500 MHz dedicated to biomolecular NMR applications. The large UCSD scientific community and several research institutes nearby (The Salk Institute for Biological Studies, the Scripps Research Institute and the Sanford Burnham Prebys Medical Discovery Institute) provide a vast network and potential for collaborations and scientific exchange. In addition to a vibrant scientific environment, San Diego also offers beautiful weather all year round and many opportunities for nature and ocean exploration.

Interested candidates should contact Dr. Debelouchina directly at with a cover letter, CV and email addresses of two references.

Representative publications:

  • Debelouchina GT, Bayro MJ, Fitzpatrick AWP, Ladizhansky V, Colvin MT, Caporini MA, Jaroniec CP, Bajaj VS, Rosay M, MacPhee C, Vendruscolo M, Maas WE, Dobson CM, Griffin RG (2013). Higher Order Amyloid Fibril Structure by MAS NMR and DNP Spectroscopy. J. Am. Chem. Soc. 135, 19237-47.
  • Debelouchina GT, Bayro MJ, van der Wel PCA, Caporini MA, Barnes AB, Rosay M, Maas WE, Griffin RG (2010). Dynamic Nuclear Polarization Enhanced Solid-State NMR Spectroscopy of GNNQQNY Crystals and Amyloid Fibrils. Phys. Chem. Chem. Phys. 12, 5911-9.
  • Hu KN, Debelouchina GT, Smith AA, Griffin RG (2011). Quantum Mechanical Theory of Dynamic Nuclear Polarization in Solid Dielectrics. J. Chem. Phys. 134, 125105.
  • Dane EL, Maly T, Debelouchina GT, Griffin RG, Swager TM (2009). Synthesis of a BDPA-TEMPO Biradical. Org. Lett. 11, 1871-4.
Galia Debelouchina, Ph.D.
Assistant Professor
Department of Chemistry and Biochemistry
University of California, San Diego
9500 Gilman Drive
La Jolla, CA 92093

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A message from the International EPR Society

Below is a message from the International EPR Society to members for the EPR and Magnetic Resonance Community. I typically don't post these kind of advertisements but I do believe the International EPR Society has done a lot of great work for the community over the many years.

Take a look at Membership fees are very low and the EPR Newsletter is a nice treat.

Dear EPR users,

To continue to have a vibrant, diverse, and active EPR community, we will all benefit from a scientific organization that offers a support and communication infrastructure for EPR -- this is what the International EPR Society ( aspires to offer. 

The most familiar faces of IES may be the EPR Newsletters and the Silver and Gold Medals for EPR. 

IES is the only international scientific organization that represents the whole range of important research fields of electron paramagnetic resonance (EPR) spectroscopy and EPR imaging (EMRI). These methods are used as the main research tools over a very wide range of fields, including physics, chemistry, life sciences, materials research and medicine.

IES is a world-wide association of scientists, and the IES mailing list serves the community to help spread EPR-related information (jobs, post-doc and PhD positions, conferences, etc.) to the world-wide EPR community. It provides public networking, available to IES members, where one can post messages via the EPR Newsletter (EPRNL), the official IES publication. EPRNL not only provides information on the availability of second-hand EPR instrumentation, it also publishes advertisements of prominent manufacturers of EPR instrumentation.

Members of IES have free access to the EPRNL! See:

IES also awards prizes and honors for outstanding contributions to EPR spectroscopy, from senior to young investigators! The newly created IES poster prizes honor excellent young scientists and PhD students for their contributions to international EPR conferences. All these achievements are reported in the EPRNL, and you can find more about "Why IES" here:

The member fees are encouragingly low: $6/year for students, $12/year for emeritus and post-doctoral fellows, and $36/year for full members. We will be happy if you paid the membership dues for several years. See:
Your membership of the IES is what will keep IES relevant, vibrant and impactful, and give IES the necessary tools to be responsive to the ever emerging field of EPR spectroscopy. 

Songi Han, Vice President (America) of IES
Thomas Prisner, President of IES

Friday, August 3, 2018

High-Resolution 2D NMR of Disordered Proteins Enhanced by Hyperpolarized Water

Szekely, O., G. L. Olsen, I. C. Felli, and L. Frydman. “High-Resolution 2D NMR of Disordered Proteins Enhanced by Hyperpolarized Water.” Analytical Chemistry, March 26, 2018.

This study demonstrates the usefulness derived from relying on hyperpolarized water obtained by dissolution DNP, for site-resolved biophysical NMR studies of intrinsically disordered proteins. Thanks to the facile amide-solvent exchange experienced by protons in these proteins, 2D NMR experiments that like HMQC rely on the polarization of the amide protons, can be enhanced using hyperpolarized water by several orders of magnitude over their conventional counterparts. Optimizations of the DNP procedure and of the subsequent injection into the protein sample are necessary to achieve these gains while preserving state-of-the-art resolution; procedures enabling this transfer of the hyperpolarized water and the achievement of foamless hyperpolarized protein solutions are demonstrated. These protocols are employed to collect 2D (15)N-(1)H HMQC NMR spectra of alpha-synuclein, showing residue-specific enhancements >/=100x over their thermal counterparts. These enhancements, however, vary considerably throughout the residues. The biophysics underlying this residue-specific behavior upon injection of hyperpolarized water is theoretically examined, the information that it carries is compared with results arising from alternative methods, and its overall potential is discussed.

Wednesday, August 1, 2018

Hyperpolarized Laplace NMR

Telkki, Ville-Veikko. “Hyperpolarized Laplace NMR.” Magnetic Resonance in Chemistry 0, no. 0 (2018).

Laplace nuclear magnetic resonance (NMR), dealing with NMR relaxation and diffusion experiments, reveals details of molecular motion and provides chemical resolution complementary to NMR spectra. Laplace NMR has witnessed a great progress in past decades due to the development of methodology and signal processing, and it has lots of extremely interesting applications in various fields, including chemistry, biochemistry, geology, archaeology, and medicine. The aim of this minireview is to give a pedagogically oriented overview of Laplace NMR. It does not provide a full literature review of the field, but, instead, it elucidate the benefits and features of Laplace NMR methods through few selected examples. The minireview describes also recent progress in multidimensional Laplace NMR and Laplace inversion methods. Furthermore, the potential of modern hyperpolarization methods as well as ultrafast approach to increase the sensitivity and time-efficiency of the Laplace NMR experiments is highlighted.