Tuesday, May 15, 2018

[NMR] Postdoctoral position in Lewandowski group at University of Warwick, UK - solid-state & solution NMR of natural products megasynthesases

A 2-year ERC-funded postdoc position is available in the Lewandowski group (http://go.warwick.ac.uk/lewandowskigroup) in the Department of Chemistry at the University of Warwick, United Kingdom.

Duration: 2 years | Start: Aug-Sept 2018 | Application deadline: 22 June 2018

The applicant will work on a major ERC-funded project employing combination of chemical biology, solid-state and solution-state NMR to study the structures, dynamics and interactions of domains from within polyketide synthases in order to facilitate their rational engineering for synthetic biology applications. Polyketide synthases are multicomponent enzymatic assembly lines for a range of useful natural products, for example, antibiotics that are effective against certain multidrug resistant infections. 

Experience in applying solution and/or solid-state NMR spectroscopy to elucidating the structures and/or dynamics of proteins is advantageous and a good knowledge of techniques for the overproduction and purification of recombinant proteins is essential.

The applicant will join a highly interdisciplinary collaborative team (exposure to a wide range of expertise and high potential for picking up new skills) under the supervision of Józef Lewandowski (http://go.warwick.ac.uk/lewandowskigroup) and in collaboration with Greg Challis (https://warwick.ac.uk/fac/sci/chemistry/research/challis/challisgroup).

The Warwick Laboratory for Magnetic Resonance (http://www2.warwick.ac.uk/fac/sci/physics/research/condensedmatt/nmr/) is a world-class biological and material science magnetic resonance set up hosting 7 academic staff from Physics and Chemistry and housing a suite of 9 solid-state NMR spectrometers (from 100 to 850 MHz; the main spectrometers for the biomolecular applications are 500, 600 and 700 MHz + access to 850 MHz and soon 1 GHz through a national facility at Warwick; a ¾ of 700 MHz solid-state NMR spectrometer time is dedicated to the project), 2 dynamic nuclear polarization (DNP) spectrometers (94 and 200/400 GHz) and advanced EPR instrumentation. A wide range of magic angle spinning probes is available in the laboratory including several 1.3 mm Bruker probes (< 67 kHz spinning), 1 mm JEOL probe, 0.81 mm Samoson probe (100 kHz spinning) and 3x 0.7 mm Bruker probes (111 kHz spinning). Solution NMR facilities include 500, 600 and 700 MHz equipped with cryoprobe (https://warwick.ac.uk/fac/sci/chemistry/research/facilities/nmr/). We have access to the state of the art mass spec facilities (https://warwick.ac.uk/fac/sci/chemistry/research/facilities/massspec) and X-ray crystallography.
The Chemical Biology Research Facility at University of Warwick (https://warwick.ac.uk/fac/sci/chemistry/research/facilities/chembiolfacility/) provides cutting edge infrastructure for organic synthesis, molecular biology, protein chemistry, microbiology, radiochemistry, biophysical and biochemical analysis.

Informal inquiries should be directed to Józef Lewandowski (j.r.lewandowski@warwick.ac.uk) and formal applications submitted (deadline Jun 22 2018). at https://atsv7.wcn.co.uk/search_engine/jobs.cgi?owner=5062452&ownertype=fair&jcode=1727027&vt_template=1457&adminview=1

Another postdoctoral position on a related BBSRC-funded project will become available in June-July 2018.


Józef R. Lewandowski
Associate Professor | Department of Chemistry | University of Warwick
j.r.lewandowski@warwick.ac.uk | External: +44 (0) 24 76151355 | Internal: 51355 

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