Monday, November 27, 2017

[NMR] Postdoc in Fast MAS Methods, ETH Zurich

Postdoctoral Position in NMR Methods developement in the solid-state NMR group of Prof. Beat Meier at ETH Zürich

Our research is centred around solid-state NMR structure determination of biomolecules (fibrils, membrane proteins, protein-DNA complexes). Increasing the presently accessible MAS frequencies (150 kHz) to 200-250 kHz will improve dramatically the spectral quality and will, when successful, lead to a greatly improved resolution in the solid-state NMR spectra of large biological systems, e.g. amyloid fibrils, membrane proteins, virus capsids and proteins assemblies. However, new pulse sequencies will be needed for faster MAS.
The project will focus on the development of novel pulse sequences for assignment and structure determination under fast MAS NMR spectroscopy. The theoretical and numerical spin-dynamics simulation work will be closely linked to experimental verification on model proteins. The experimental work can be started with the equipment presently available in the lab at 110-150 kHz MAS. Spectrometers at 500, 600, 850 (2x) and, in the future 1100 MHz are available. See also http://nmr.ethz.ch

Prerequisites: Ph.D. in Chemistry, Physics, Biology, Interdisciplinary Sciences, or related area, experience in solid-state NMR and NMR methodological development. Motivation to work in a multidisciplinary team.

Applications with motivation letter, CV, publication list, and contact information for 2 references should be sent directly to Prof. Beat Meier (beme@ethz.ch). Applications will be accepted until Dec 20.


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