Monday, December 5, 2016

High-Resolution Two-Field Nuclear Magnetic Resonance Spectroscopy

Cousin, S.F., et al., High-Resolution Two-Field Nuclear Magnetic Resonance Spectroscopy. Phys. Chem. Chem. Phys., 2016.

Nuclear Magnetic Resonance (NMR) is a ubiquitous branch of spectroscopy that can explore matter on the scale of the atom. Significant improvements in sensitivity and resolution have been driven by a steady increase of static magnetic field strengths. However, some properties of nuclei may be more favourable at low magnetic fields. For example, line-broadening due to chemical shift anisotropy increases sharply at higher magnetic fields. Here, we present a two-field NMR spectrometer that permits the application of rf-pulses and acquisition of NMR signals in two magnetic centres. Our prototype operates at 14.1 T and 0.33 T. The main features of this system are demonstrated by novel NMR experiments that correlate zero-quantum coherences at low magnetic field with single quantum coherences at high magnetic field, so that high resolution can be achieved in both dimensions, despite a ca. 10 ppm inhomogeneity of the low field centre. Two-field NMR spectroscopy offers the possibility to circumvent the limits of high magnetic fields, while benefiting from their exceptional sensitivity and resolution. This approach opens new avenues for NMR above 1 GHz.