Friday, October 14, 2016

Renal MR angiography and perfusion in the pig using hyperpolarized water

Wigh Lipso, K., et al., Renal MR angiography and perfusion in the pig using hyperpolarized water. Magn Reson Med, 2016: p. n/a-n/a.

PURPOSE: To study hyperpolarized water as an angiography and perfusion tracer in a large animal model. METHODS: Protons dissolved in deuterium oxide (D2 O) were hyperpolarized in a SPINlab dissolution dynamic nuclear polarization (dDNP) polarizer and subsequently investigated in vivo in a pig model at 3 Tesla (T). Approximately 15 mL of hyperpolarized water was injected in the renal artery by hand over 4-5 s. RESULTS: A liquid state polarization of 5.3 +/- 0.9% of 3.8 M protons in 15 mL of deuterium oxide was achieved with a T1 of 24 +/- 1 s. This allowed injection through an arterial catheter into the renal artery and subsequently high-contrast imaging of the entire kidney parenchyma over several seconds. The dynamic images allow quantification of tissue perfusion, with a mean cortical perfusion of 504 +/- 123 mL/100 mL/min. CONCLUSION: Hyperpolarized water MR imaging was successfully demonstrated as a renal angiography and perfusion method. Quantitative perfusion maps of the kidney were obtained in agreement with literature and control experiments with gadolinium contrast. Magn Reson Med, 2016. (c) 2016 International Society for Magnetic Resonance in Medicine.