Jagtap, A.P., et al., bcTol: a highly water-soluble biradical for efficient dynamic nuclear polarization of biomolecules. Chem Commun (Camb), 2016. 52(43): p. 7020-3.
Dynamic nuclear polarization (DNP) is an efficient method to overcome the inherent low sensitivity of magic-angle spinning (MAS) solid-state NMR. We report a new polarizing agent (), designed for biological applications, that yielded an enhancement value of 244 in a microcrystalline SH3 domain sample at 110 K.