Friday, December 4, 2015

Application of Good's buffers to pH imaging using hyperpolarized (13)C MRI


Flavell, R.R., et al., Application of Good's buffers to pH imaging using hyperpolarized (13)C MRI. Chem Commun (Camb), 2015. 51(74): p. 14119-22.


N-(2-Acetamido)-2-aminoethanesulfonic acid (ACES), one of Good's buffers, was applied to pH imaging using hyperpolarized (13)C magnetic resonance spectroscopy. Rapid NMR- and MRI-based pH measurements were obtained by exploiting the sensitive pH-dependence of its (13)C chemical shift within the physiologic range.