Friday, August 7, 2015

Design of a hyperpolarized 15N NMR probe that induces a large chemical-shift change upon binding of calcium ions


Hata, R., et al., Design of a hyperpolarized 15N NMR probe that induces a large chemical-shift change upon binding of calcium ions. Chemical Communications, 2015. 51(61): p. 12290-12292.


Ca2+ is a fundamental metal ion for physiological functioning. Therefore, molecular probes for Ca2+ analysis are required. Recently, a hyperpolarized NMR probe has emerged as a promising tool. Here, we report a new design of a hyperpolarized NMR probe for Ca2+, which showed a large chemical shift change upon binding to Ca2+ and was applied for Ca2+ sensing in a hyperpolarized state.