Friday, July 12, 2013

Solid-State NMR Spectroscopy of Proteins

A nice review about solid-state NMR spectroscopy with some solid-state DNP.

Müller, H., M. Etzkorn, and H. Heise, Solid-State NMR Spectroscopy of Proteins, in Modern NMR Methodology, H. Heise and S. Matthews, Editors. 2013, Springer Berlin Heidelberg. p. 121-156.

Solid-state NMR spectroscopy proved to be a versatile tool for characterization of structure and dynamics of complex biochemical systems. In particular, magic angle spinning (MAS) solid-state NMR came to maturity for application towards structural elucidation of biological macromolecules. Current challenges in applying solid-state NMR as well as progress achieved recently will be discussed in the following chapter focusing on conceptual aspects important for structural elucidation of proteins.