Tuesday, April 16, 2013

MR Physicist/Engineer Position for Hyperpolarized DNP NMR/MRI

This was originally posted on the ISMRM webpage at: http://www.ismrm.org/jobs/J04941.pdf

MR Physicist/Engineer Position for Hyperpolarized DNP NMR/MRI

Applications are invited for the position of a MR physicist/engineer in the Department of Radiology and Biomedical Imaging at the University of California San Francisco (UCSF). The successful candidate will be responsible for Dynamic Nuclear Polarization (DNP) instrumentation development and maintenance at the UCSF Hyperpolarized MRI Technology Resource Center. This position will work closely with collaborators to design and test new methods & hardware for dissolution DNP hyperpolarized MR molecular imaging preclinical and clinical research studies.

Facility and Equipment:

The UCSF Hyperpolarized MRI Technology Resource Center encompasses equipment in the UCSF Surbeck Laboratory for Advanced MR Imaging and the adjacent UCSF Biochemical NMR lab equipped with: 1) Five DNP polarizers (3 Oxford Instruments HyperSense systems, an alpha-version Proof-ofConcept, & a GE SpinLab multi-sample clinical-research polarizer); 2) A GE 3T and 7T whole-body MRI scanners; 3) A Vertical bore Varian/Agilent 11.7T NMR & 14.1T wide-bore Micro-Imaging NMR system; and 4) Access to Bruker 500, 600, and 800 MHz NMR’s. The center facilities also include an electronics shop and a machine shop. For more information please visit the center website at: 


Job Description and Responsibilities: Hyperpolarized MRI using dissolution Dynamic Nuclear Polarization (DNP) is an emerging imaging technique which uses specialized hardware & methods to  provide signal enhancements of over 5-orders of magnitude for carbon-13 enriched compounds. The  resulting hyperpolarized solution then can be injected in a MR scanner to detect not only the uptake of the targeted molecule, but also its metabolic products in vivo using rapid 13C MR acquisitions. This  extraordinary new technique has the potential to become a major new MR metabolic imaging technique  by providing valuable new information on previously-inaccessible aspects of biological processes by  detecting endogenous, nontoxic 13C-labeled probes that can monitor enzymatic conversions through key biochemical pathways. UCSF has established a major research center in HP DNP MR for cell, tissue, & in vivo studies with expanding engineering needs and opportunities. This new staff position will be responsible for the development and maintenance of specialized DNP polarizer hardware for cutting-edge preclinical and clinical research using hyperpolarized MR molecular imaging.


We are seeking individuals who have experience in NMR, super-conducting magnets, cryogenic  hardware, team-oriented collaborative research, and who have a desire to learn or prior experience in  DNP polarizer hardware engineering. Experience in operating and maintaining NMR systems, troubleshooting on the hard- and software side, machine shop tooling, and knowledge in RF design will be an  advantage. UCSF is an equal opportunity employer. Women and minorities are encouraged to apply.

Please Apply to:

Jenny Che: jenny.che@ucsf.edu
Program Manager, Hyperpolarized MRI Technology Resource Center
UCSF Byers Hall MC2512, 1700 4th St, San Francisco, CA 94158