Wednesday, January 16, 2013

DNP Spectroscopy to characterize small molecules

The last year has seen a tremendous amount of scientific articles published in the area of Dynamic Nuclear Polarization (DNP) and hyperpolarization in general. There are several articles that demonstrate the large potential of DNP-NMR spectroscopy and I will select a few of them in the coming weeks in a combined post.

Check out these two articles that were published last year (if you haven't done so already):

Lee, D., et al., Enhanced solid-state NMR correlation spectroscopy of quadrupolar nuclei using dynamic nuclear polarization. J Am Chem Soc, 2012. 134(45): p. 18491-4.

Rossini, A.J., et al., Dynamic nuclear polarization NMR spectroscopy of microcrystalline solids. J Am Chem Soc, 2012. 134(40): p. 16899-908.

Both demonstrate the large potential of DNP-NMR spectroscopy to study small molecules with only natural abundance level 13C labels. In both articles 2D 13C-13C correlation spectra of the unlabeled material are shown that would require days of signal averaging without the aid of DNP.