Sunday, March 11, 2012

PASADENA Hyperpolarized 13C Phospholactate

Shchepin, R.V., et al., PASADENA Hyperpolarized 13C Phospholactate. J. Am. Chem. Soc., 2012. 134(9): p. 3957-3960.


We demonstrate that potassium 1-13C-phosphoenolpyruvate becomes hyperpolarized potassium 1-13C-phospholactate with 13C T1 = 36 s after molecular hydrogenation by PASADENA (Parahydrogen and Synthesis Allows Dramatically Enhanced Nuclear Alignment). This proof-of-principle study was conducted with a fully protonated molecular precursor. 13C was polarized to a level of 1%, corresponding to nearly 4000-fold sensitivity enhancement at 3 T. The relevant homo- and heteronuclear spin?spin couplings are reported.